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      MCSG Screens 
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“Crystal Former is very easy to set up and handle during follow-up visual inspection. It offers unique capabilities of gradient screening.  It speeds up the whole process of crystallization. For some projects it helps us identify novel crystallization hits.”

Dr Nickolay Chirgadze
University Health Network, Toronto

   Upcoming Events:
 
ICCBM 13
September 12-16th, 2010
Dublin, Ireland
 
PSDI Meeting
November 14-17th, 2010
Oxford, UK


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Terese Bergfors: 
“We use the Crystal
Former as part of our
overall crystallization
strategy..."
 


 
  Products
Microlytic Screens
Description: 
At Microlytic, 3 different screening options are available. The SmartScreen and PurePEGs are more geared towards diffusive mixing and often used in combination with Crystal Former chips. The MCSG Screening Suites, composed of 4 96 condition screens, is designed to be flexible and used both with vapor diffusion setups or any other setups.
 
The SmartScreen is a custom screen consisting of 48 conditions as 3x16 solution sets, which have been selected from many published sparse screens.  Each well contains approximately 75ul of screen arranged in order of productivity (1 is best, 2 second best, etc…).  Only microliter (ul) volumes are required with the Crystal Former. 

-The first 16 conditions should give crystals for over 65% of protein
-The next 16 should raise that number to over 85%
-The last 16 should produce more than 94% crystal growth.

These numbers are based on published data from vapor diffusion experiments.  Higher yields should be expected based on the feedback from customers currently using the Crystal Former (ask about our case studies).

The PurePEGs screen features conditions with a mixture of purified PEGs, ranging from 300 MW to 8,000 MW. At a total PEG concentration of 22.5 % (1), combined with various salts and buffers, the conditions are designed to give the most crystallization hits spanning a wide pH range (1.1 - 9.8).
 
 
New MCSG Screens: Composed of MCSG 1-4 Screens, offered in a 96 well 1.7 ml deep well block format.
  • 384 Crystallization Conditions
  • Broad coverage of Crystallization Space
  • Optimized suite developed through high throughput validation
  • Most successful conditions at the Midwest Center for Structural Genomics
  • Validated proteins derived from both prokaryotic and eukaryotic organisms
 
 
 
For Formulation Sheets and White Papers please see Documentation
 
 
 
 
Name
SmartScreen MLS-1


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PurePEGs MLY-1


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MCSG Screening Suite 1-4


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Microlytic , 300 Trade Center, Suite 3650, Woburn MA 01801
Phone: +1 781 376 0780  |  Fax: +1 781 376 0785  |  © 2009 Microlytic ApS