Crystal Former Success Stories
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Crystal Formers aid product development! |
Crystal Formers have been implemented in a number of product development ventures in recent months. In one such project, an RNA binding protein from the hyperthermophile Thermococcus... |
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Bacterial Drug Targets |
Methicillin-resistant Staphylococcus aureus and Helicobacter pylori are two major bacterial pathogens with direct impact on human health. MRSA exhibits resistance to the broad-spectrum... |
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LeuT Integral Membrane Protein |
Integral membrane proteins comprise a highly challenging class of structural biology targets. The LeuT transporter has a bundle of 12 alpha-helices that for a transport channel through the... |
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Malaria Drug Targets |
Malaria is a life-threatening disease caused by the Plasmodium parasite that is transmitted to the human host through mosquito bites. In 2008, the World Health Organization... |
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Crystallization of a Par polarity complex component |
Crystallization screening with the Crystal Former permits the exploration of a broad area of crystallization space. Owing to the gradients formed during liquid-liquid diffusion, it becomes... |
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Optimization of vapor diffusion crystals with the Crystal Former |
"AstraZeneca in Sweden have used the 16 channel Crystal Former scale-up chip for optimization of poorly-diffracting vapor diffusion hits. By using the compatible holders they set-up the... |
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Loading and Crystallization with the Echo Acoustic Ejector |
Recent tests of the Original Crystal Formers with the Echo acoustic liquid handler from Labcyte (... |
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4KLV | read more | |
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4KUB | read more |
Crystal Former References
(7) Manjasetty BA, Bussow K, Panjikar S & Turnbull AP (2012) Current methods in structural proteomics and its applications in biological sciences. 3BioTech,Springer Open DOI:10.1007/s13205-011-0037-1
(6) Hoffman ID (2012) Chapter 4: Protein crystallization for structure-based drug design. LTari LW(Ed). Structure-Based Drug Discovery, Methods in Molecular Biology 841. DOI: 10.1007/978-1-61779-520-6_4
(5) Garcia-Caballero A, Gavira JA, Pineda-Molina E, Chayen NE, Govada L, Khurshid S, Saridakis E, Boudjemline A, Swann MJ, Shaw Stewart P, Briggs RA, Kolek SA, Oberthuer D, Dierks K, Betzel C, Sanatana M, Hobbs JR, Thaw P, Savil TJ, Mesters JR, Hilgenfeld R, Bonander N, & Bill RM (2011) Optimization of Protein crystallization: The OptiCryst Project. Crystal Growth & Design 11, 2112-2121 DOI:10.1021/cg1013768
(4) Stojanoff V, Jakoncic J, Oren DA, Nagarajan V, Navarro Poulsen JC, Adams-Cioaba MA, Bergfors T & Sommer MOA (2011). From Screen to structure with a harvestable microfluidic device. Acta Cryst F67:971-975. DOI:10.1107/S174430911102445
(3) Stewart PDS, Kolek SA, Briggs RA, Chayen NE & Baldock PFM (2011) Random microseeding: a theoretical and practical exploration of seed stability and seeding techniques for successful protein crystallization. Cryst. Growth Des. DOI: 10.1021/cg2001442.
(2) Gerdts C * Nollert P (2009). Advances in microfluidic membrane protein crystallization techniques. Current Topics in Membranes, 63: 179-189. DOI: 10.1016/S1063-5823(09)63008-8
(1) Bergfors T (2009) The rapid crystallization strategy for structure-based inhibitor design. From molecules to medicines: Structure of biological macromolecules and its relevance in combating new diseases and bioterrorism. Sussman JL & Spadon P. Eds. ISBN 978-90-481-2337-7
Crystal Former - Conference Presentations
(1) Weger A, Kim YC, Adams-Cioaba MA, Sommer M & Joachimiak A (2010) Microfluidic Crystal Formers for high throughput screening and optimization. NIGMS Workshop: Enabling technologies in structure and function. View Here
